I am a mathematician and a pianist by training. I started playing the piano from the age of three, and I studied mathematics as my major at university and earned my PhD at the University of Edinburgh in 2015. My in-depth mathematical training gained at university has allowed me to further explore many other fields and to contribute to those that requires knowledge and tools from measure theory, stochastic processes, probability and statistics, game theory and optimisation. After developing novel models in queueing theory during my PhD research, and gaining extensive experience as a quantitative researcher in the financial industry, I arrived at my current research field of dementia.
My current research project aims to untangle the heterogeneity in AD by finding subtypes of the clinical appearance of AD suggested by the trajectories of brain imaging, fluid biomarkers and measurements of cognitive capability. We study how other risk factors (including comorbidities, life-style factors and genetics) influence the patterns of brain shrinkage and loss of brain function years before the disease becomes severe, aiming to provide insights to potential lifestyle interventions at early stages that may affect or delay disease onset, and will enable the enrichment of future clinical trials for specific groups of patients who are likely to benefit from a particular treatment.
Academic Publications
Fluid and Diffusion Limits for Probabilistic Matching Systems,
B. Buke and H. Chen, Queueing Systems, 86: p1 – p33, Springer, Jun 2017
Stabilizing Policies for Probabilistic Matching Systems,
B. Buke and H. Chen, Queueing Systems, 80: p35 – p69, Springer, Jun 2015